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pubmed:abstractText |
Chest pain is a hallmark of myocardial ischemia, but its underlying signaling mechanisms remain poorly understood. The capsaicin receptor, vanilloid receptor-1 (VR1), is an important cation channel present on primary nociceptive neurons. We have shown that the VR1 is expressed on sensory nerve endings of the heart. In the present study, we determined the role of VR1s in activation of cardiac spinal afferent nerves caused by myocardial ischemia.
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pubmed:affiliation |
Department of Anesthesiology, H187, Pennsylvania State University College of Medicine, and the Milton S. Hershey Medical Center, 500 University Dr, Hershey, PA 17033-0850, USA. hpan@psu.edu
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