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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-5-15
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pubmed:abstractText |
The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1679987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1760843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1879366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1884999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1885000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1925551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-1997208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2028256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2081472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2103885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-212715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2199796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2226210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2238086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2242162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2403844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2476281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2493990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2507923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2598265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2598266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-2688897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-3001650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-3345559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-3345560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-3416836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-3683556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-6258458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533042-6275366
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:geneSymbol |
sim
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3414-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1533042-Adenovirus Early Proteins,
pubmed-meshheading:1533042-Alleles,
pubmed-meshheading:1533042-Animals,
pubmed-meshheading:1533042-Base Sequence,
pubmed-meshheading:1533042-Blastoderm,
pubmed-meshheading:1533042-DNA-Binding Proteins,
pubmed-meshheading:1533042-Drosophila,
pubmed-meshheading:1533042-Embryo, Nonmammalian,
pubmed-meshheading:1533042-Genes,
pubmed-meshheading:1533042-Molecular Sequence Data,
pubmed-meshheading:1533042-Oligodeoxyribonucleotides,
pubmed-meshheading:1533042-Oncogene Proteins, Viral,
pubmed-meshheading:1533042-Promoter Regions, Genetic,
pubmed-meshheading:1533042-Zinc Fingers,
pubmed-meshheading:1533042-beta-Galactosidase
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pubmed:year |
1992
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pubmed:articleTitle |
Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.
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pubmed:affiliation |
Department of Biology, University of California, Los Angeles 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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