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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-1
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pubmed:abstractText |
T helper cell type 2 (Th2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells. Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells. We demonstrate that anti-interleukin 4, as well as anti-LFA-1 antibodies interfere with the T-B cell interaction. In kinetic studies, anti-LFA-1 was found to be operative during the first half and anti-interleukin 4 during the second half of the 48-h culture period. This defines at least two different steps in B cell triggering by Th2 cells. In addition, the data imply that the T-B cell interaction involves an additional structure, namely an activation molecule, on the T cell surface.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
599-602
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1531640-Animals,
pubmed-meshheading:1531640-Antibodies, Monoclonal,
pubmed-meshheading:1531640-Antigens, CD3,
pubmed-meshheading:1531640-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1531640-B-Lymphocytes,
pubmed-meshheading:1531640-Cells, Cultured,
pubmed-meshheading:1531640-Female,
pubmed-meshheading:1531640-Interleukin-4,
pubmed-meshheading:1531640-Lymphocyte Activation,
pubmed-meshheading:1531640-Lymphocyte Cooperation,
pubmed-meshheading:1531640-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:1531640-Mice,
pubmed-meshheading:1531640-Mice, Inbred BALB C,
pubmed-meshheading:1531640-Receptors, Antigen, T-Cell,
pubmed-meshheading:1531640-T-Lymphocytes,
pubmed-meshheading:1531640-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1531640-Time Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Two signals are involved in polyclonal B cell stimulation by T helper type 2 cells: a role for LFA-1 molecules and interleukin 4.
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pubmed:affiliation |
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, FRG.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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