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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-16
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pubmed:abstractText |
Androgen receptor (AR) has a pivotal role in the growth and proliferation of prostate cancer (PCa). Even in advanced stages of PCa AR continues to be expressed and appears to be functional. Since the mechanisms of AR activation in androgen independent PCa have yet to be clearly defined, the decrease in AR protein by antisense compounds is an attractive therapeutic option. In this study we evaluated a novel antisense phosphorodiamidate morpholino oligomer (PMO) targeting the translational start site of AR mRNA in vitro and in vivo in a PCa xenograft and murine prostate.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1140-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15311058-Animals,
pubmed-meshheading:15311058-Cell Line, Tumor,
pubmed-meshheading:15311058-Cells, Cultured,
pubmed-meshheading:15311058-Chromatography, High Pressure Liquid,
pubmed-meshheading:15311058-Dose-Response Relationship, Drug,
pubmed-meshheading:15311058-Down-Regulation,
pubmed-meshheading:15311058-HeLa Cells,
pubmed-meshheading:15311058-Humans,
pubmed-meshheading:15311058-Luciferases,
pubmed-meshheading:15311058-Male,
pubmed-meshheading:15311058-Mice,
pubmed-meshheading:15311058-Mice, Nude,
pubmed-meshheading:15311058-Morpholines,
pubmed-meshheading:15311058-Morpholinos,
pubmed-meshheading:15311058-Neoplasm Transplantation,
pubmed-meshheading:15311058-Oligonucleotides, Antisense,
pubmed-meshheading:15311058-Prostate,
pubmed-meshheading:15311058-Prostate-Specific Antigen,
pubmed-meshheading:15311058-Prostatic Neoplasms,
pubmed-meshheading:15311058-Protein Biosynthesis,
pubmed-meshheading:15311058-Receptors, Androgen,
pubmed-meshheading:15311058-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.
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pubmed:affiliation |
Cancer Biology Program, Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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