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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
41
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pubmed:dateCreated |
2004-10-6
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pubmed:databankReference |
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pubmed:abstractText |
Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TRIB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TRIB3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/tribbles protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:BagstaffStephanie MSM,
pubmed-author:CauntJim CJC,
pubmed-author:DempseyClareC,
pubmed-author:DowerSteven KSK,
pubmed-author:HarteMaryM,
pubmed-author:JozsaVeronikaV,
pubmed-author:Kiss-TothEndreE,
pubmed-author:O'neillLuke A JLA,
pubmed-author:OxleyKevin MKM,
pubmed-author:PolgarTimeaT,
pubmed-author:QwarnstromEva EEE,
pubmed-author:SungHye YHY,
pubmed-author:WyllieDavid HDH
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
42703-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15299019-Animals,
pubmed-meshheading:15299019-Blotting, Western,
pubmed-meshheading:15299019-Cell Cycle Proteins,
pubmed-meshheading:15299019-Dose-Response Relationship, Drug,
pubmed-meshheading:15299019-Drosophila Proteins,
pubmed-meshheading:15299019-Enzyme Activation,
pubmed-meshheading:15299019-Gene Expression Regulation,
pubmed-meshheading:15299019-Genes, Reporter,
pubmed-meshheading:15299019-HeLa Cells,
pubmed-meshheading:15299019-Humans,
pubmed-meshheading:15299019-Immunoprecipitation,
pubmed-meshheading:15299019-Interleukin-1,
pubmed-meshheading:15299019-Interleukin-8,
pubmed-meshheading:15299019-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15299019-Luciferases,
pubmed-meshheading:15299019-MAP Kinase Signaling System,
pubmed-meshheading:15299019-Mice,
pubmed-meshheading:15299019-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15299019-Models, Biological,
pubmed-meshheading:15299019-Molecular Sequence Data,
pubmed-meshheading:15299019-NIH 3T3 Cells,
pubmed-meshheading:15299019-Oligonucleotides, Antisense,
pubmed-meshheading:15299019-Plasmids,
pubmed-meshheading:15299019-Protein Binding,
pubmed-meshheading:15299019-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15299019-Repressor Proteins,
pubmed-meshheading:15299019-Transfection,
pubmed-meshheading:15299019-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
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pubmed:affiliation |
Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom. E.Kiss-Toth@sheffield.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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