Source:http://linkedlifedata.com/resource/pubmed/id/15296752
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
2004-8-6
|
| pubmed:abstractText |
Cells of metazoan organisms respond to DNA damage by arresting their cell cycle to repair DNA, or they undergo apoptosis. Two protein kinases, ataxia-telangiectasia mutated (ATM) and ATM and Rad-3 related (ATR), are sensors for DNA damage. In humans, ATM is mutated in patients with ataxia-telangiectasia (A-T), resulting in hypersensitivity to ionizing radiation (IR) and increased cancer susceptibility. Cells from A-T patients exhibit chromosome aberrations and excessive spontaneous apoptosis. We used Drosophila as a model system to study ATM function. Previous studies suggest that mei-41 corresponds to ATM in Drosophila; however, it appears that mei-41 is probably the ATR ortholog. Unlike mei-41 mutants, flies deficient for the true ATM ortholog, dATM, die as pupae or eclose with eye and wing abnormalities. Developing larval discs exhibit substantially increased spontaneous chromosomal telomere fusions and p53-dependent apoptosis. These developmental phenotypes are unique to dATM, and both dATM and mei-41 have temporally distinct roles in G2 arrest after IR. Thus, ATM and ATR orthologs are required for different functions in Drosophila; the developmental defects resulting from absence of dATM suggest an important role in mediating a protective checkpoint against DNA damage arising during normal cell proliferation and differentiation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...,
http://linkedlifedata.com/resource/pubmed/chemical/meiotic 41 protein, Drosophila
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0960-9822
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1354-9
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| pubmed:dateRevised |
2011-11-2
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| pubmed:meshHeading |
pubmed-meshheading:15296752-Animals,
pubmed-meshheading:15296752-Apoptosis,
pubmed-meshheading:15296752-Blotting, Northern,
pubmed-meshheading:15296752-Cell Cycle Proteins,
pubmed-meshheading:15296752-DNA Damage,
pubmed-meshheading:15296752-DNA-Binding Proteins,
pubmed-meshheading:15296752-Drosophila,
pubmed-meshheading:15296752-Drosophila Proteins,
pubmed-meshheading:15296752-Eye,
pubmed-meshheading:15296752-Female,
pubmed-meshheading:15296752-Fertility,
pubmed-meshheading:15296752-Gene Expression Regulation, Developmental,
pubmed-meshheading:15296752-In Situ Nick-End Labeling,
pubmed-meshheading:15296752-Larva,
pubmed-meshheading:15296752-Microscopy, Electron, Scanning,
pubmed-meshheading:15296752-Mitosis,
pubmed-meshheading:15296752-Phylogeny,
pubmed-meshheading:15296752-Protein Structure, Tertiary,
pubmed-meshheading:15296752-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15296752-Tumor Suppressor Proteins,
pubmed-meshheading:15296752-Wing,
pubmed-meshheading:15296752-X-Rays
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| pubmed:year |
2004
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| pubmed:articleTitle |
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
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| pubmed:affiliation |
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th St., Charlestown, MA 02129, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|