|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2004-8-5
|
|
pubmed:abstractText |
The evaluation of a sulfonamide inhibitor of the p53-mdm2 interaction is presented. The compound was identified using 3D database searching techniques based on a computationally derived pharmacophore model of mdm2 binding. It inhibits the physical interaction of recombinant p53 and mdm2 in vitro and increases p53-dependent transcription in an mdm2-overexpressing cell line.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2004 American Chemical Society
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
12
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4163-5
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15293988-Cell Line, Tumor,
pubmed-meshheading:15293988-Databases, Factual,
pubmed-meshheading:15293988-Genes, Reporter,
pubmed-meshheading:15293988-Humans,
pubmed-meshheading:15293988-Luciferases,
pubmed-meshheading:15293988-Nuclear Proteins,
pubmed-meshheading:15293988-Protein Binding,
pubmed-meshheading:15293988-Proto-Oncogene Proteins,
pubmed-meshheading:15293988-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:15293988-Quantitative Structure-Activity Relationship,
pubmed-meshheading:15293988-Structure-Activity Relationship,
pubmed-meshheading:15293988-Sulfonamides,
pubmed-meshheading:15293988-Transcriptional Activation,
pubmed-meshheading:15293988-Tumor Suppressor Protein p53
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
|
|
pubmed:publicationType |
Journal Article
|
