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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2004-7-30
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pubmed:abstractText |
Activated pancreatic stellate cells (PSCs) are implicated in the pathogenesis of pancreatic inflammation and fibrosis, where oxidative stress is thought to play a key role. 4-hydroxy-2,3-nonenal (HNE) is generated endogenously during the process of lipid peroxidation, and has been accepted as a mediator of oxidative stress. The aim of this study was to clarify the effects of HNE on the activation of signal transduction pathways and cellular functions in PSCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1007-9327
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2344-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15285017-Aldehydes,
pubmed-meshheading:15285017-Animals,
pubmed-meshheading:15285017-Cell Culture Techniques,
pubmed-meshheading:15285017-Cell Division,
pubmed-meshheading:15285017-Cell Survival,
pubmed-meshheading:15285017-Enzyme Activation,
pubmed-meshheading:15285017-Growth Inhibitors,
pubmed-meshheading:15285017-Lipid Peroxidation,
pubmed-meshheading:15285017-Male,
pubmed-meshheading:15285017-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15285017-NF-kappa B,
pubmed-meshheading:15285017-Oxidative Stress,
pubmed-meshheading:15285017-Pancreas,
pubmed-meshheading:15285017-Rats,
pubmed-meshheading:15285017-Rats, Wistar,
pubmed-meshheading:15285017-Signal Transduction,
pubmed-meshheading:15285017-Transcription Factor AP-1
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pubmed:year |
2004
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pubmed:articleTitle |
4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.
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pubmed:affiliation |
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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