Source:http://linkedlifedata.com/resource/pubmed/id/15269840
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-7-22
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| pubmed:abstractText |
Monocytes play a central role in the inflammatory disease atherosclerosis. CD14+CD16+ monocytes are considered proinflammatory monocytes, as they have an increased capacity to produce proinflammatory cytokines, such as TNF-alpha, and are elevated in various inflammatory diseases. We hypothesized that patients with coronary artery disease (CAD) have increased levels of CD14+CD16+ monocytes, and that CD14+CD16+ monocytes are associated with inflammation markers. We investigated CD14+CD16+ monocytes in 247 patients with CAD and 61 control subjects using flow cytometry. In addition serum concentrations of TNF-alpha, IL-6, and Hs-CRP were assessed. Patients with CAD had higher levels of CD14+CD16+ monocytes than controls (13.6% versus 11.4%; p<0.001). Logistic regression analysis including quartiles of CD14+CD16+ monocytes showed that CD14+CD16+ monocytes were associated with prevalence of CAD (OR 4.9, 95% CI 2.5-19.1, for subjects in the fourth quartile in comparison to subjects in the first quartile). The association between CD14+CD16+ monocytes and CAD remained independently significant after adjustment for most potential confounders (OR 5.0, 95% CI 1.2-20.0). Serum concentrations of TNF-alpha were elevated in subjects within the highest quartiles of CD14+CD16+ monocytes (p=0.018). Our study showed that increased numbers of CD14+CD16+ monocytes are associated with coronary atherosclerosis and TNF-alpha. In accordance, recent animal studies suggest a possibly important role of these monocytes in the development of atherosclerosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0340-6245
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| pubmed:author |
pubmed-author:BickelChristophC,
pubmed-author:BlankenbergStefanS,
pubmed-author:DariusHaraldH,
pubmed-author:DopheideJoern FJF,
pubmed-author:Espinola-KleinChristineC,
pubmed-author:HeineGunnar HGH,
pubmed-author:IzMeteM,
pubmed-author:LacknerKarl JKJ,
pubmed-author:MeyerJuergenJ,
pubmed-author:RupprechtHans JHJ,
pubmed-author:SchlittAxelA
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| pubmed:issnType |
Print
|
| pubmed:volume |
92
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
419-24
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15269840-Aged,
pubmed-meshheading:15269840-Analysis of Variance,
pubmed-meshheading:15269840-Antibodies, Monoclonal,
pubmed-meshheading:15269840-Antigens, CD14,
pubmed-meshheading:15269840-Arteriosclerosis,
pubmed-meshheading:15269840-Body Mass Index,
pubmed-meshheading:15269840-Case-Control Studies,
pubmed-meshheading:15269840-Cell Separation,
pubmed-meshheading:15269840-Coronary Artery Disease,
pubmed-meshheading:15269840-Female,
pubmed-meshheading:15269840-Flow Cytometry,
pubmed-meshheading:15269840-Humans,
pubmed-meshheading:15269840-Inflammation,
pubmed-meshheading:15269840-Interleukin-6,
pubmed-meshheading:15269840-Logistic Models,
pubmed-meshheading:15269840-Male,
pubmed-meshheading:15269840-Middle Aged,
pubmed-meshheading:15269840-Monocytes,
pubmed-meshheading:15269840-Odds Ratio,
pubmed-meshheading:15269840-Receptors, IgG,
pubmed-meshheading:15269840-Risk Factors,
pubmed-meshheading:15269840-Tumor Necrosis Factor-alpha
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| pubmed:year |
2004
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| pubmed:articleTitle |
CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels.
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| pubmed:affiliation |
Department of Medicine II and Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany. axelschlitt@gmx.net
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| pubmed:publicationType |
Journal Article
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