15252125

Source:http://linkedlifedata.com/resource/pubmed/id/15252125

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013138, umls-concept:C0205144, umls-concept:C0205378, umls-concept:C0599896, umls-concept:C1160050
pubmed:issue	Pt 16
pubmed:dateCreated	2004-7-14
pubmed:abstractText	The cellularization that converts the syncytial Drosophila embryo into thousands of distinct cells is a hybrid form of cleavage. It derives from cytokinesis and has acquired specific features required for epithelial biogenesis. Cellularization generates an epithelial layer in which adjacent cells are connected by apical adherens junctions. If this process goes awry, subsequent development is dramatically affected, in particular tissue remodelling during gastrulation. Cellularization is associated with the invagination of the plasma membrane between adjacent nuclei at the cell cortex, the formation of a basal-lateral surface and the assembly of apical adherens junctions. The regulated mobilization of intracellular pools of vesicles at defined sites of the plasma membrane underlies membrane growth and surface polarization. Genetic approaches have identified conserved core cellular pathways required for these processes, such as vesicular trafficking along the biosynthetic and endocytic routes, and vesicular insertion into the plasma membrane. The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0052457
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0021-9533
pubmed:author	pubmed-author:LecuitThomasT
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	117
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3427-33
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15252125-Adherens Junctions, pubmed-meshheading:15252125-Animals, pubmed-meshheading:15252125-Drosophila, pubmed-meshheading:15252125-Endocytosis, pubmed-meshheading:15252125-Endosomes
pubmed:year	2004
pubmed:articleTitle	Junctions and vesicular trafficking during Drosophila cellularization.
pubmed:affiliation	Laboratoire de Génétique et de Physiologie du Développement, UMR 6545 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille, Campus de Luminy, case 907, 13288 Marseille CEDEX 09, France. lecuit@ibdm@univ-mrs.fr
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't