Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5681
pubmed:dateCreated
2004-7-12
pubmed:abstractText
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1095-9203
pubmed:author
pubmed-author:BianchiMarinaM, pubmed-author:BianchiRobertoR, pubmed-author:BrinesMichaelM, pubmed-author:Cerami-HandCarlaC, pubmed-author:CeramiAnthonyA, pubmed-author:ChristensenSørenS, pubmed-author:ColemanThomasT, pubmed-author:ErbayraktarSerhatS, pubmed-author:ErbayraktarZubeydeZ, pubmed-author:FratelliMaddalenaM, pubmed-author:GerwienJensJ, pubmed-author:GhezziPietroP, pubmed-author:GokmenNecatiN, pubmed-author:GrassoGiovanniG, pubmed-author:HelboeLoneL, pubmed-author:KallunkiPekkaP, pubmed-author:LarsenAnna KirstineAK, pubmed-author:LeistMarcelM, pubmed-author:NielsenJacobJ, pubmed-author:NielsenMetteM, pubmed-author:PedersenLars OLO, pubmed-author:SagerThomasT, pubmed-author:SavinoCostanzaC, pubmed-author:SfacteriaAlessandraA, pubmed-author:TorupLarsL, pubmed-author:VillaPiaP, pubmed-author:XieQiao-WenQW, pubmed-author:YilmazOsmanO
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-42
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15247477-Animals, pubmed-meshheading:15247477-Apoptosis, pubmed-meshheading:15247477-Binding Sites, pubmed-meshheading:15247477-Cells, Cultured, pubmed-meshheading:15247477-Diabetic Neuropathies, pubmed-meshheading:15247477-Drug Design, pubmed-meshheading:15247477-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:15247477-Erythropoiesis, pubmed-meshheading:15247477-Erythropoietin, pubmed-meshheading:15247477-Female, pubmed-meshheading:15247477-Hematocrit, pubmed-meshheading:15247477-Humans, pubmed-meshheading:15247477-Ligands, pubmed-meshheading:15247477-Mice, pubmed-meshheading:15247477-Mice, Inbred C3H, pubmed-meshheading:15247477-Mutagenesis, pubmed-meshheading:15247477-Nervous System Diseases, pubmed-meshheading:15247477-Neurons, pubmed-meshheading:15247477-Neuroprotective Agents, pubmed-meshheading:15247477-Rats, pubmed-meshheading:15247477-Rats, Sprague-Dawley, pubmed-meshheading:15247477-Receptors, Erythropoietin, pubmed-meshheading:15247477-Recombinant Proteins, pubmed-meshheading:15247477-Signal Transduction, pubmed-meshheading:15247477-Spinal Cord Compression, pubmed-meshheading:15247477-Stroke, pubmed-meshheading:15247477-Structure-Activity Relationship
pubmed:year
2004
pubmed:articleTitle
Derivatives of erythropoietin that are tissue protective but not erythropoietic.
pubmed:affiliation
H. Lundbeck A/S, 2500 Valby, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't