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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP2. TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR and RAMP1/2 mRNAs, thereby diminishing AM-evoked cAMP production. The suppression of these three mRNAs was unaffected by inhibiting NOS, protein kinase G, protein kinase A, superoxide formation or NF-kappaB activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CALCRL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Receptor-Like Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAMP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RAMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1115-21
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15245870-Calcitonin Receptor-Like Protein,
pubmed-meshheading:15245870-Cells, Cultured,
pubmed-meshheading:15245870-Coronary Vessels,
pubmed-meshheading:15245870-Down-Regulation,
pubmed-meshheading:15245870-Humans,
pubmed-meshheading:15245870-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15245870-Membrane Proteins,
pubmed-meshheading:15245870-Myocytes, Smooth Muscle,
pubmed-meshheading:15245870-Receptor Activity-Modifying Protein 1,
pubmed-meshheading:15245870-Receptor Activity-Modifying Protein 2,
pubmed-meshheading:15245870-Receptor Activity-Modifying Proteins,
pubmed-meshheading:15245870-Receptors, Adrenomedullin,
pubmed-meshheading:15245870-Receptors, Calcitonin,
pubmed-meshheading:15245870-Receptors, Peptide,
pubmed-meshheading:15245870-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells.
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pubmed:affiliation |
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, 889-1692, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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