Source:http://linkedlifedata.com/resource/pubmed/id/15225709
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
2004-6-30
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| pubmed:abstractText |
A series of lysine sulfonamide analogues bearing a Nepsilon-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nalpha-(alkyl)-Nalpha-(sulfonamides)lysinol using alpha-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3971-4
|
| pubmed:meshHeading |
pubmed-meshheading:15225709-HIV,
pubmed-meshheading:15225709-HIV Protease Inhibitors,
pubmed-meshheading:15225709-Kinetics,
pubmed-meshheading:15225709-Lysine,
pubmed-meshheading:15225709-Molecular Structure,
pubmed-meshheading:15225709-Structure-Activity Relationship,
pubmed-meshheading:15225709-Sulfonamides
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-disubstituted ureas.
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| pubmed:affiliation |
Procyon Biopharma Inc., 1650 Trans-Canada Highway, Suite 200, Dorval, Quebec, Canada, H9P 1H7. bstranix@procyonbiopharma.com
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| pubmed:publicationType |
Journal Article
|