Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-7-19
pubmed:abstractText
1 Nabumetone is a prodrug that is converted in vivo into 6-methoxy-2-naphthylacetic acid (6MNA), a cyclooxygenase inhibitor with anti-inflammatory properties. We tested the effects of nabumetone and 6MNA on the inflammatory responses of synovial fibroblasts (SFs). 2 Brief exposures to 6MNA (50-150 microm) had no effect on IL-1beta/TNF-alpha (each 20 ng ml(-1))-stimulated Erk activation. Longer exposures depleted prostaglandin E1 (PGE1) as much as 70%, and stimulated Erk as much as 300%. Nabumetone (150 microm) inhibited Erk activation by 60-80%. 6MNA (50-150 microm) stimulated (approximately 200%) and nabumetone (150 microm) inhibited (approximately 50%) matrix metalloproteinase (MMP)-1, but not MMP-13 secretion from SFs. 3 6MNA stimulation of MMP-1 secretion was inhibited approximately 30% by PGE1 (1 microm) and approximately 80% by the Erk pathway inhibitor UO126 (10 microm), confirming that PGE depletion and Erk activation mediate MMP-1 secretion by 6MNA. 4 Consistent with its role as an Erk inhibitor, nabumetone (150 microm) abrogated 6MNA enhancement of MMP-1 secretion. 5 UO126 (10 microm) and nabumetone (150 microm) inhibited (approximately 70 and 40%, respectively), but 6MNA (150 microm) enhanced (approximately 40%), NF-kappaB activation. 6 Our data indicate that 6MNA shares with other COX inhibitors several proinflammatory effects on synovial fibroblasts. In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10377455, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10428782, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10442486, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10623853, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10753891, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10765924, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10801894, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-10960075, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11276273, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11284783, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11396097, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11450703, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11590203, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11829533, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-11908571, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12009331, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12010565, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12183632, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12237340, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12375328, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-12635655, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-1377121, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-144506, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-14634122, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-176663, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-2081495, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-2846503, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-3436484, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-5003042, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-6464502, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-7750577, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-7809384, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8036523, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8052854, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8078306, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8288614, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8626494, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-8756539, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9101367, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9435990, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9538225, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9597130, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9660836, http://linkedlifedata.com/resource/pubmed/commentcorrection/15210577-9826736
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/6-methoxy-2-naphthylacetic acid, http://linkedlifedata.com/resource/pubmed/chemical/Alprostadil, http://linkedlifedata.com/resource/pubmed/chemical/Butadienes, http://linkedlifedata.com/resource/pubmed/chemical/Butanones, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Naphthaleneacetic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins E, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/SB 203580, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/U 0126, http://linkedlifedata.com/resource/pubmed/chemical/nabumetone
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
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