| pubmed-article:15193300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C1152805 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C0205221 | lld:lifeskim |
| pubmed-article:15193300 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:15193300 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15193300 | pubmed:dateCreated | 2004-6-14 | lld:pubmed |
| pubmed-article:15193300 | pubmed:abstractText | The developing rodent brain is vulnerable to pharmacological blockade of N-methyl-d-aspartate (NMDA) receptors which can lead to severe and disseminated apoptotic neurodegeneration. Here, we show that systemic administration of the NMDA receptor antagonist MK801 to 7-day-old rats leads to impaired activity of extracellular signal-regulated kinase 1/2 (ERK1/2) and reduces levels of phosphorylated cAMP-responsive element binding protein (CREB) in brain regions which display severe apoptotic neurodegeneration. Impaired ERK1/2 and CREB activity were temporally paralleled by sustained depletion of neurotrophin expression, particularly brain-derived neurotrophic factor (BDNF). BDNF supplementation fully prevented MK801-induced neurotoxicity in immature neuronal cultures and transgenic constitutive activation of Ras was associated with marked protection against MK801-induced apoptotic neuronal death. These data indicate that uncoupling of NMDA receptors from the ERK1/2-CREB signaling pathway in vivo results in massive apoptotic deletion of neurons in the developing rodent brain. | lld:pubmed |
| pubmed-article:15193300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15193300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15193300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15193300 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15193300 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:StepulakAndrz... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:HansenHenrik... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:IkonomidouChr... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:HeumannRolfR | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:BittigauPetra... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:RzeskiWojciec... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:SifringerMarc... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:DzietkoMarkM | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:ZdzisinskaBar... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:ThorFriederik... | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:BriemTimT | lld:pubmed |
| pubmed-article:15193300 | pubmed:author | pubmed-author:VossAlexander... | lld:pubmed |
| pubmed-article:15193300 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15193300 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:15193300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15193300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15193300 | pubmed:pagination | 440-53 | lld:pubmed |
| pubmed-article:15193300 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15193300 | pubmed:meshHeading | pubmed-meshheading:15193300... | lld:pubmed |
| pubmed-article:15193300 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15193300 | pubmed:articleTitle | Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain. | lld:pubmed |
| pubmed-article:15193300 | pubmed:affiliation | Department of Pediatric Neurology,Campus Virchow Klinikum, and Neuroscience Research Center, Charité, Humboldt University, 10117, Berlin, Germany. henrik.hansen@charite.de | lld:pubmed |
| pubmed-article:15193300 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15193300 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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