Linked Life Data

15188438

Source:http://linkedlifedata.com/resource/pubmed/id/15188438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-6-9
pubmed:abstractText
We have identified a new mutation, spoonbill (spoon), which interferes with two developmental processes during Drosophila oogenesis, nurse cell-nuclei chromatin organization and anterior-dorsal patterning of the eggshell. Here, we describe the localization patterns of key regulators of axis determination and the expression of follicle cell-specific markers involved in eggshell patterning in egg chambers from spoonbill females. Our molecular characterization of the patterning defects associated with the mutation reveals abnormalities in two major signaling pathways, the grk/Egfr and the Dpp/TGF-beta, that together control the elaborate patterning of the anterior follicular epithelium. The function of spoonbill appears to be required for dpp transcription in a specialized population of follicle cells and for the selective transport of grk mRNA from the nurse cells into the oocyte, as well as for its proper localization and translation. This finding places the spoonbill gene upstream of both pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1058-8388
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
230
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
535-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
spoonbill, a new Drosophila female-sterile mutation, interferes with chromosome organization and dorsal-ventral patterning of the egg.
pubmed:affiliation
Department of Molecular Genetics of Development, Faculty of Health Sciences, Ben-Gurion University Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't