Linked Life Data

15174374

Source:http://linkedlifedata.com/resource/pubmed/id/15174374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-6-3
pubmed:abstractText
In this article the results of investigations of interrelation between radio-induced apoptosis in larvae nervous system and aging in imago are presented. It was shown that the apoptosis level of larvae nervous ganglion 2.5 folds increased after exposure to ionizing radiation (54 cGy). Irradiation of stocks with higher apoptosis induction sensitivity, bearing mutations of inhibitor apoptosis protein th (allele th1 and th4) and wild type strain Berlin leaded to elevation of activity at all ages and accordingly to decreasing of aging speed. Whereas in stocks with lower apoptosis induction sensitivity (with mutations of genes rpr, grim, hid, dArk and Dcp-1) this effect was not observed. The obtained results suggested that radiation-induced apoptosis could be one of the mechanisms preventing aging.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0869-8031
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
156-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Aging rate after continual low dose irradiation of drosophila strains with apoptosis deregulation].
pubmed:affiliation
Institute of Biology, Komi Science Center of Russian Academy of Science, Syktyvkar, 167983 Russia. amoskalev@ib.komisc.ru
pubmed:publicationType
Journal Article, English Abstract