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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-6-2
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pubmed:abstractText |
Although prostate-specific antigen (PSA) is a prototypic biomarker for prostate cancer, it has poor specificity. Expression of alpha-methylacyl-CoA racemase (AMACR), which is involved in the conversion of R-stereoisomers of branched-chain fatty acids to S-stereoisomers, has been shown to be specifically increased in prostate cancer epithelia. However, attempts to detect AMACR in circulation have not been successful. Hence, we determined whether an immune response to AMACR could be used as a serum biomarker for prostate cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1460-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
834-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15173267-Adult,
pubmed-meshheading:15173267-Aged,
pubmed-meshheading:15173267-Aged, 80 and over,
pubmed-meshheading:15173267-Autoantibodies,
pubmed-meshheading:15173267-Case-Control Studies,
pubmed-meshheading:15173267-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15173267-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15173267-Humans,
pubmed-meshheading:15173267-Immunoblotting,
pubmed-meshheading:15173267-Male,
pubmed-meshheading:15173267-Middle Aged,
pubmed-meshheading:15173267-Prostate-Specific Antigen,
pubmed-meshheading:15173267-Prostatic Neoplasms,
pubmed-meshheading:15173267-Protein Array Analysis,
pubmed-meshheading:15173267-Racemases and Epimerases,
pubmed-meshheading:15173267-Sensitivity and Specificity,
pubmed-meshheading:15173267-Tumor Markers, Biological
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pubmed:year |
2004
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pubmed:articleTitle |
Humoral immune response to alpha-methylacyl-CoA racemase and prostate cancer.
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pubmed:affiliation |
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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