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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-10-8
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pubmed:abstractText |
A cadmium-resistant strain of Saccharomyces cerevisiae produces a cadmium metallothionein encoded by the CUP1 gene as does a copper-resistant strain. The mechanism of expression of the gene is inducible by copper ions in the copper-resistant strain. However, assays of CUP1-specific mRNA revealed that the transcription of the CUP1 gene in the cadmium-resistant strain is constitutive and the rate of transcription is further increased by exposure to cadmium or copper ions. This result was confirmed by the appearance of constitutive-expression segregants from diploid crosses between the cadmium-resistant strain and a strain with a reporter gene having the promoter of CUP1.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0378-1097
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
74
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pubmed:geneSymbol |
CUP1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1516810-Cadmium,
pubmed-meshheading:1516810-Copper,
pubmed-meshheading:1516810-Drug Resistance, Microbial,
pubmed-meshheading:1516810-Gene Expression Regulation, Fungal,
pubmed-meshheading:1516810-Genes, Fungal,
pubmed-meshheading:1516810-Metallothionein,
pubmed-meshheading:1516810-Promoter Regions, Genetic,
pubmed-meshheading:1516810-Saccharomyces cerevisiae,
pubmed-meshheading:1516810-Transcription, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Constitutive transcription of the gene for metallothionein in a cadmium-resistant yeast.
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pubmed:affiliation |
Department of Biology, Faculty of Science, Ehime University, Matsuyama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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