rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1992-10-8
|
pubmed:abstractText |
The Tn, sialosyl-Tn, and T antigens are carbohydrate-associated antigens that represent initial steps in mucin O-linked glycosylation. Previous immunohistochemical studies have shown that these three antigens are rarely, if ever, expressed in normal colonic mucosa; however, most colonic cancerous tissues express these structures. Little is known about the factors that control the expression of these antigens in colonic tissues or cell lines. One hypothesis is that cancers have increased levels of the glycosyltransferase activities responsible for synthesizing these antigens.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Tumor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral, Tumor,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Tn antigen,
http://linkedlifedata.com/resource/pubmed/chemical/sialosyl-Tn antigen
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0008-543X
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
70
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1467-76
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1515998-Aged,
pubmed-meshheading:1515998-Antigens, Neoplasm,
pubmed-meshheading:1515998-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:1515998-Antigens, Viral, Tumor,
pubmed-meshheading:1515998-Colonic Neoplasms,
pubmed-meshheading:1515998-Glycosylation,
pubmed-meshheading:1515998-Glycosyltransferases,
pubmed-meshheading:1515998-Humans,
pubmed-meshheading:1515998-Immunoenzyme Techniques,
pubmed-meshheading:1515998-Male,
pubmed-meshheading:1515998-Middle Aged,
pubmed-meshheading:1515998-Mucins,
pubmed-meshheading:1515998-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Mucin oligosaccharide biosynthesis in human colonic cancerous tissues and cell lines.
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pubmed:affiliation |
Gastrointestinal Research Laboratory, VA Medical Center, San Francisco, California.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|