| pubmed-article:15147897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C0206518 | lld:lifeskim |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:15147897 | lifeskim:mentions | umls-concept:C0815278 | lld:lifeskim |
| pubmed-article:15147897 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:15147897 | pubmed:dateCreated | 2004-5-18 | lld:pubmed |
| pubmed-article:15147897 | pubmed:abstractText | Neurosteroids are known as allosteric modulators of ionotropic gamma-aminobutyric acid (GABA) receptors. Here, we investigated sites of positive allosteric modulation by allotetrahydrodeoxycorticosterone (5alpha-THDOC) at GABA receptors using the technique of chimeragenesis and the Xenopus oocyte expression system. Our findings have demonstrated that the region from transmembrane segment (TM) 4 to the C-terminus of the GABA(A) receptor alpha1 subunit is crucial for the action of 5alpha-THDOC, but insufficient for the action of another neurosteroid allopregnanolone, suggesting that a specific region critical for neurosteroid action at GABA receptors exists in the domain between TM4 and the C-terminus of GABA receptor subunits. | lld:pubmed |
| pubmed-article:15147897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15147897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15147897 | pubmed:month | May | lld:pubmed |
| pubmed-article:15147897 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:15147897 | pubmed:author | pubmed-author:MinamiKouichi... | lld:pubmed |
| pubmed-article:15147897 | pubmed:author | pubmed-author:UenoSusumuS | lld:pubmed |
| pubmed-article:15147897 | pubmed:author | pubmed-author:TsutsuiMasato... | lld:pubmed |
| pubmed-article:15147897 | pubmed:author | pubmed-author:YanagiharaNob... | lld:pubmed |
| pubmed-article:15147897 | pubmed:author | pubmed-author:ToyohiraYumik... | lld:pubmed |
| pubmed-article:15147897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15147897 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15147897 | pubmed:volume | 566 | lld:pubmed |
| pubmed-article:15147897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15147897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15147897 | pubmed:pagination | 213-7 | lld:pubmed |
| pubmed-article:15147897 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
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| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
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| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
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| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:meshHeading | pubmed-meshheading:15147897... | lld:pubmed |
| pubmed-article:15147897 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15147897 | pubmed:articleTitle | Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits. | lld:pubmed |
| pubmed-article:15147897 | pubmed:affiliation | Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 807-8555, Japan. susumu@med.uoeh-u.ac.jp | lld:pubmed |
| pubmed-article:15147897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15147897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15147897 | lld:pubmed |
