| pubmed-article:15147830 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C1711178 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C1424650 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15147830 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15147830 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15147830 | pubmed:dateCreated | 2004-5-18 | lld:pubmed |
| pubmed-article:15147830 | pubmed:abstractText | The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamma (IFN-gamma) (100 U/ml) induced phosphorylation of p44/42 MAPK. The MEK inhibitor U0126 (0.1 to 10 microM) enhanced the TPA-induced ICAM-1 expression but not the IFN-gamma-induced one. U0126 also enhanced the ICAM-1 expression induced by two other PKC activators teleocidin (22.5 nM) and aplysiatoxin (14.9 nM). Furthermore, PD98059 (0.5 to 50 microM), another MEK inhibitor, enhanced the TPA-induced ICAM-1 expression as well. The inhibitor of p38 MAPK SB203580 did not affect the TPA-induced ICAM-1 expression. BAY11-7082, an inhibitor of nuclear factor kappaB (NF-kappaB) activation, and MG132, a 26S proteasome inhibitor, reduced the TPA-induced ICAM-1 expression but not the IFN-gamma-induced one. TPA partially decreased the level of IkappaB-alpha and the reduction was further augmented by U0126 in a concentration-dependent manner. These findings suggested that, in NCI-H292 cells, p44/42 MAPK suppresses PKC activator-induced NF-kappaB activation, thus negatively regulating the PKC activator-induced ICAM-1 expression but not the IFN-gamma-induced one. | lld:pubmed |
| pubmed-article:15147830 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15147830 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15147830 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15147830 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15147830 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:OhuchiKazuoK | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:HirasawaNoriy... | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:YamashitaMasa... | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:TakayanagiMot... | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:ShibuyaYuhkoY | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:SakaiTakumiT | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:TogashiYuhkoY | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:MuramatsuRiek... | lld:pubmed |
| pubmed-article:15147830 | pubmed:author | pubmed-author:IshiiKen-Ichi... | lld:pubmed |
| pubmed-article:15147830 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15147830 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:15147830 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:15147830 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15147830 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15147830 | pubmed:pagination | 435-46 | lld:pubmed |
| pubmed-article:15147830 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:15147830 | pubmed:meshHeading | pubmed-meshheading:15147830... | lld:pubmed |
| pubmed-article:15147830 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15147830 | pubmed:articleTitle | Negative regulation of the protein kinase C activator-induced ICAM-1 expression in the human bronchial epithelial cell line NCI-H292 by p44/42 mitogen-activated protein kinase. | lld:pubmed |
| pubmed-article:15147830 | pubmed:affiliation | Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. | lld:pubmed |
| pubmed-article:15147830 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15147830 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15147830 | lld:pubmed |
