|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-5-17
|
|
pubmed:abstractText |
In the present study, we demonstrate that sodium butyrate repressed IFN-gamma-induced expression of iNOS and TNF-alpha, but had little effect on LPS-induced expression in BV2 murine microglial cells. Sodium butyrate significantly inhibited NF-kappa B binding and NF-kappa B-mediated transcription induced by IFN-gamma, suggesting that the anti-inflammatory effect of sodium butyrate is mediated via specific inhibition of the NF-kappa B pathway. IFN-gamma is a major stimulator of innate and adaptive immune response. Thus, the specific down-regulation of IFN-gamma-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
151
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
85-93
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15145607-Animals,
pubmed-meshheading:15145607-Blotting, Western,
pubmed-meshheading:15145607-Butyric Acid,
pubmed-meshheading:15145607-Cells, Cultured,
pubmed-meshheading:15145607-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:15145607-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15145607-Interferon-gamma,
pubmed-meshheading:15145607-Lipopolysaccharides,
pubmed-meshheading:15145607-Mice,
pubmed-meshheading:15145607-Microglia,
pubmed-meshheading:15145607-NF-kappa B,
pubmed-meshheading:15145607-Nitric Oxide,
pubmed-meshheading:15145607-Nitric Oxide Synthase,
pubmed-meshheading:15145607-Nitric Oxide Synthase Type II,
pubmed-meshheading:15145607-Recombinant Proteins,
pubmed-meshheading:15145607-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15145607-Signal Transduction,
pubmed-meshheading:15145607-Transfection,
pubmed-meshheading:15145607-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia.
|
|
pubmed:affiliation |
Department of Neuroscience, Ewha Institute of Neuroscience and Medical Research Center, College of Medicine, Ewha Woman's University, Seoul, South Korea. hskimp@mm.ewha.ac.kr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
