Linked Life Data

15143335

Source:http://linkedlifedata.com/resource/pubmed/id/15143335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-7-20
pubmed:abstractText
Gastrointestinal phenotype in cervical adenocarcinomas was examined by immunohistochemistry and correlated with morphologic features. Antibody panels included anti-MUC2, MUC6, CD10, chromogranin A (CGA) and HIK1083. In addition, expression of p16INK4, a cyclin-dependent kinase inhibitor which is expressed in a variety of high-risk HPV-related conditions, was studied. A total of 94 invasive adenocarcinomas including 20 minimal deviation adenocarcinomas (MDAs) and 72 adenocarcinomas in situ (AIS) were examined. MDAs were most frequently positive for HIK1083 and/or MUC6, two representative gastric markers, with a rate of 95%, followed by intestinal-type adenocarcinomas (IAs) with a rate of 85% whereas only 27% of 56 usual endocervical-type adenocarcinomas (UEAs) were positive. MUC2, a goblet cell marker, was positive in 85% and 25% of IAs and MDAs, respectively, while in only 14% of UEAs. CD10 was positive in 15% of IAs, indicating incomplete intestinal differentiation without a brush border in most of the cases. CGA-positive cells were frequently seen in MDAs and IAs with rates of 60% and 62%, respectively. Nuclear and cytoplasmic p16INK4 positivity was identified in 93% of UEAs, whereas 30% of MDAs were positive for p16INK4. Results in AISs were comparable to their invasive counterparts, but morphologically usual-type AISs identified in eight cases of MDA were frequently positive for HIK1083 (75%) and MUC6 (63%), and p16INK4. Of note was the existence of lobular endocervical glandular hyperplasia (LEGH) with atypical features including cytologic abnormalities, and/or papillary projection, which were identified in this study in pure form (n=3) or in association with MDAs (n=6), but not in cases of other types of adenocarcinomas. These observations indicate that gastrointestinal phenotype is frequently expressed in MDAs and IAs, and there seems to be a possible link between MDA, and LEGH and morphologically usual-type AIS with gastric immunophenotype in histogenesis. Frequent absence of p16INK4 expression in MDAs suggests a possibility that high-risk HPV does not play a crucial role in development of MDAs, in contrast to the majority of endocervical adenocarcinomas. p16INK4 immunohistochemistry appears to be a promising diagnostic tool, but pathologists should be aware of frequent negative staining in MDAs, which can be a source of erroneous diagnosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0893-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
962-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15143335-Adenocarcinoma, pubmed-meshheading:15143335-Adenoma, pubmed-meshheading:15143335-Chromogranin A, pubmed-meshheading:15143335-Chromogranins, pubmed-meshheading:15143335-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:15143335-Female, pubmed-meshheading:15143335-Gastric Mucins, pubmed-meshheading:15143335-Gastric Mucosa, pubmed-meshheading:15143335-Gastrointestinal Neoplasms, pubmed-meshheading:15143335-Humans, pubmed-meshheading:15143335-Hyperplasia, pubmed-meshheading:15143335-Immunohistochemistry, pubmed-meshheading:15143335-Metaplasia, pubmed-meshheading:15143335-Mucin-2, pubmed-meshheading:15143335-Mucin-6, pubmed-meshheading:15143335-Mucins, pubmed-meshheading:15143335-Neoplasms, Glandular and Epithelial, pubmed-meshheading:15143335-Neprilysin, pubmed-meshheading:15143335-Uterine Cervical Neoplasms
pubmed:year
2004
pubmed:articleTitle
Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'.
pubmed:affiliation
Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan. mika@patholo2.med.tohoku.ac.jp
pubmed:publicationType
Journal Article, Comparative Study