Linked Life Data

15143284

Source:http://linkedlifedata.com/resource/pubmed/id/15143284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5673
pubmed:dateCreated
2004-5-14
pubmed:abstractText
Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP. In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production. These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
304
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1021-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15143284-2-Amino-5-phosphonovalerate, pubmed-meshheading:15143284-Animals, pubmed-meshheading:15143284-Calcium, pubmed-meshheading:15143284-Electric Stimulation, pubmed-meshheading:15143284-Excitatory Amino Acid Antagonists, pubmed-meshheading:15143284-Excitatory Postsynaptic Potentials, pubmed-meshheading:15143284-Hippocampus, pubmed-meshheading:15143284-Long-Term Potentiation, pubmed-meshheading:15143284-Long-Term Synaptic Depression, pubmed-meshheading:15143284-Patch-Clamp Techniques, pubmed-meshheading:15143284-Phenols, pubmed-meshheading:15143284-Piperidines, pubmed-meshheading:15143284-Pyramidal Cells, pubmed-meshheading:15143284-Rats, pubmed-meshheading:15143284-Rats, Sprague-Dawley, pubmed-meshheading:15143284-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:15143284-Synapses, pubmed-meshheading:15143284-Synaptic Transmission
pubmed:year
2004
pubmed:articleTitle
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.
pubmed:affiliation
Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't