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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-1-11
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pubmed:abstractText |
Stress-related glucocorticoid and glutamate release have been implicated in hippocampal atrophy evident in patients with post-traumatic stress disorder (PTSD). Glutamatergic mechanisms activate nitric oxide synthase (NOS), while gamma-amino-butyric acid (GABA) may inhibit both glutamatergic and nitrergic transmission. Animal studies support a role for NOS in stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Indazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoconazole,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/pimagedine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
494-502
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15138761-Animals,
pubmed-meshheading:15138761-Chromatography, High Pressure Liquid,
pubmed-meshheading:15138761-Corticosterone,
pubmed-meshheading:15138761-Electrochemistry,
pubmed-meshheading:15138761-Enzyme Inhibitors,
pubmed-meshheading:15138761-Guanidines,
pubmed-meshheading:15138761-Hippocampus,
pubmed-meshheading:15138761-Indazoles,
pubmed-meshheading:15138761-Ketoconazole,
pubmed-meshheading:15138761-Kinetics,
pubmed-meshheading:15138761-Male,
pubmed-meshheading:15138761-Nitric Oxide Synthase,
pubmed-meshheading:15138761-Nitric Oxide Synthase Type I,
pubmed-meshheading:15138761-Nitric Oxide Synthase Type II,
pubmed-meshheading:15138761-Radioligand Assay,
pubmed-meshheading:15138761-Rats,
pubmed-meshheading:15138761-Rats, Sprague-Dawley,
pubmed-meshheading:15138761-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:15138761-Recurrence,
pubmed-meshheading:15138761-Stress, Psychological,
pubmed-meshheading:15138761-Stress Disorders, Post-Traumatic,
pubmed-meshheading:15138761-gamma-Aminobutyric Acid
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pubmed:year |
2004
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pubmed:articleTitle |
Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus.
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pubmed:affiliation |
Faculty of Health Sciences, Division of Pharmacology, School of Pharmacy, North West University, 2520 Potchefstroom, South Africa. fklbhh@puk.ac.za
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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