Source:http://linkedlifedata.com/resource/pubmed/id/15126112
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2004-5-5
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| pubmed:abstractText |
The present study was undertaken to investigate the effects of bone morphogenetic protein-7 (BMP-7), also named osteogenic protein-1 (OP-1), on the progression of a striatal 6-hydroxydopamine (6-OHDA) lesion. BMP-7, a member of the transforming growth factor-beta (TGF-beta) superfamily of proteins, has been shown to have protective effects in other animal models of neuronal damage. In this study, male Fischer 344 rats received striatal 6-OHDA lesions followed 1 week later by an intraventricular dose of BMP-7. No significant effect of BMP-7 treatment on spontaneous locomotor activity was observed, however BMP-7 significantly increased the density of tyrosine hydroxylase (TH) immunoreactivity (TH-ir) in the substantia nigra (SN) pars compacta, in the lesioned hemisphere [31.7+/-5.2 (optical density (O.D.) arbitrary units) control vs. 50.2+/-4.3 O.D. BMP-7-treated; p<0.05]. Interestingly, BMP-7 significantly increased TH-ir in the SN of the non-lesioned hemisphere (pars reticulata: 14.8+/-1.19 O.D. control vs. 36+/-2.6 O.D. BMP-7-treated, p<0.05; pars compacta: 29.0+/-4.9 O.D. control vs. 64.4+/-6.9 O.D. BMP-7-treated, p<0.001). A significant increase in DA concentration in the contralateral, non-lesioned hemisphere was also noted (113.2 ng/g control vs. 198.2 ng/g BMP-7-treated, p<0.01). In contrast to other intraventricularly administered neurotrophic factors, BMP-7 was not associated with an increase in the sensitivity to pain. These results suggest that BMP-7 is able to act as a dopaminotrophic agent without unwanted side effects and as such may be a useful pharmacological tool in the treatment of Parkinson's disease in humans.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
4
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| pubmed:volume |
1010
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
10-6
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15126112-Animals,
pubmed-meshheading:15126112-Bone Morphogenetic Protein 7,
pubmed-meshheading:15126112-Bone Morphogenetic Proteins,
pubmed-meshheading:15126112-Corpus Striatum,
pubmed-meshheading:15126112-Disease Models, Animal,
pubmed-meshheading:15126112-Dopamine,
pubmed-meshheading:15126112-Dose-Response Relationship, Drug,
pubmed-meshheading:15126112-Immunohistochemistry,
pubmed-meshheading:15126112-Male,
pubmed-meshheading:15126112-Motor Activity,
pubmed-meshheading:15126112-Nerve Growth Factors,
pubmed-meshheading:15126112-Neurons,
pubmed-meshheading:15126112-Oxidopamine,
pubmed-meshheading:15126112-Pain Threshold,
pubmed-meshheading:15126112-Parkinsonian Disorders,
pubmed-meshheading:15126112-Rats,
pubmed-meshheading:15126112-Rats, Inbred F344,
pubmed-meshheading:15126112-Substantia Nigra,
pubmed-meshheading:15126112-Transforming Growth Factor beta,
pubmed-meshheading:15126112-Treatment Outcome,
pubmed-meshheading:15126112-Tyrosine 3-Monooxygenase,
pubmed-meshheading:15126112-Up-Regulation
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| pubmed:year |
2004
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| pubmed:articleTitle |
Beneficial effects of intraventricularly administered BMP-7 following a striatal 6-hydroxydopamine lesion.
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| pubmed:affiliation |
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO, USA.
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| pubmed:publicationType |
Journal Article
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