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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-4-30
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pubmed:abstractText |
Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
555-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15118593-Adenocarcinoma,
pubmed-meshheading:15118593-Animals,
pubmed-meshheading:15118593-Anoikis,
pubmed-meshheading:15118593-Caspases,
pubmed-meshheading:15118593-Cell Line,
pubmed-meshheading:15118593-Focal Adhesion Kinase 1,
pubmed-meshheading:15118593-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:15118593-Gene Silencing,
pubmed-meshheading:15118593-Humans,
pubmed-meshheading:15118593-Mice,
pubmed-meshheading:15118593-Mice, Nude,
pubmed-meshheading:15118593-Pancreatic Neoplasms,
pubmed-meshheading:15118593-Protein-Tyrosine Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.
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pubmed:affiliation |
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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