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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-4-27
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pubmed:abstractText |
The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when they were stimulated with apomorphine (0.5 mg/kg, s.c.), similar to rats injected unilaterally with 6-hydroxydopamine (6-OHDA). These rats also exhibited impairment of motor and cognitive behaviours. The results support the hypothesis that DT-diaphorase plays a protective role in the nigrostriatal dopaminergic systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1029-8428
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-33
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15111240-Animals,
pubmed-meshheading:15111240-Dicumarol,
pubmed-meshheading:15111240-Drug Synergism,
pubmed-meshheading:15111240-Enzyme Inhibitors,
pubmed-meshheading:15111240-Injections, Intraventricular,
pubmed-meshheading:15111240-Isoquinolines,
pubmed-meshheading:15111240-Male,
pubmed-meshheading:15111240-Motor Activity,
pubmed-meshheading:15111240-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:15111240-Rats,
pubmed-meshheading:15111240-Rats, Sprague-Dawley,
pubmed-meshheading:15111240-Substantia Nigra
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pubmed:year |
2004
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pubmed:articleTitle |
Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats.
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pubmed:affiliation |
Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Avda. Salvador 486, Casilla 16038 Santiago-9, Chile. gdiaz@med.uchile.cl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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