Source:http://linkedlifedata.com/resource/pubmed/id/15110520
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2004-4-27
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pubmed:abstractText |
Red sea bream iridovirus (RSIV) of the Iridoviridae family is a causative agent of lethal infections in many cultured marine fish species in southwestern Japan. RSIV-induced apoptosis was divided as follows: (1). cell shrinkage and rounding at the early apoptotic stage, (2). cell enlargement at the middle apoptotic stage, (3). formation of apoptotic body-like vesicles at the late apoptotic stage and phagocytosis by neighboring cells, and (4). loss of membrane integrity in apoptotic body-like vesicles without phagocytosis by neighboring cells. By affinity labeling, RSIV-induced apoptosis included caspase-dependent apoptosis. RSIV infection caused cell rounding but not cell enlargement or formation of apoptotic body-like vesicles and further restricted part of the structural protein synthesis in the presence of caspase-3 and -6 inhibitors. These findings showed the involvement of caspase-3 and -6 in the morphological changes at the middle and late apoptotic stages and viral protein synthesis in the late stage of RSIV infection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0042-6822
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
322
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
220-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15110520-Animals,
pubmed-meshheading:15110520-Apoptosis,
pubmed-meshheading:15110520-Caspase 3,
pubmed-meshheading:15110520-Caspase 6,
pubmed-meshheading:15110520-Caspases,
pubmed-meshheading:15110520-Cysteine Proteinase Inhibitors,
pubmed-meshheading:15110520-Cytopathogenic Effect, Viral,
pubmed-meshheading:15110520-DNA Fragmentation,
pubmed-meshheading:15110520-Iridovirus,
pubmed-meshheading:15110520-Microscopy, Electron,
pubmed-meshheading:15110520-Sea Bream,
pubmed-meshheading:15110520-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
Morphological changes contribute to apoptotic cell death and are affected by caspase-3 and caspase-6 inhibitors during red sea bream iridovirus permissive replication.
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pubmed:affiliation |
Department of Aquaculture, Kochi University, Nankoku, Kochi 783-8502, Japan.
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pubmed:publicationType |
Journal Article
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