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rdf:type |
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lifeskim:mentions |
umls-concept:C0003062,
umls-concept:C0004359,
umls-concept:C0004368,
umls-concept:C0026339,
umls-concept:C0111208,
umls-concept:C0178539,
umls-concept:C0205195,
umls-concept:C0332206,
umls-concept:C0376613,
umls-concept:C0871261,
umls-concept:C1519680,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
13-14
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pubmed:dateCreated |
2004-4-7
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pubmed:abstractText |
Xenogeneic DNA vaccination can elicit tumor immunity through T cell and antibody-dependent effector mechanisms. Blockade of CTLA-4 engagement with B7 expressed on APCs has been shown to enhance T cell-dependent immunity. We investigated whether CTLA-4 blockade could increase T-cell responses and tumor immunity elicited by DNA vaccines. CTLA-4 blockade enhanced B16 tumor rejection in mice immunized against the melanoma differentiation antigens tyrosinase-related protein 2 and gp100, and this effect was stronger when anti-CTLA-4 was administered with booster vaccinations. CTLA-4 blockade also increased the T-cell responses to prostate-specific membrane antigen (PSMA) when given with the second or third vaccination. Based on these pre-clinical studies, we suggest that anti-CTLA-4 should be tested with xenogeneic DNA vaccines against cancer and that special attention should be given to sequence and schedule of administration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AllisonJames PJP,
pubmed-author:BacichDeanD,
pubmed-author:BuchinshkyHeidiH,
pubmed-author:FerroneCristina RCR,
pubmed-author:GregorPolly DPD,
pubmed-author:Guevara-PatiñoJose AJA,
pubmed-author:HestonWarrenW,
pubmed-author:HoughtonAlan NAN,
pubmed-author:LatoucheJean-BaptisteJB,
pubmed-author:MortazaviFariborzF,
pubmed-author:PeralesMiguel-AngelMA,
pubmed-author:SadelainMichelM,
pubmed-author:ScherHoward IHI,
pubmed-author:WolchokJedd DJD
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15068853-Animals,
pubmed-meshheading:15068853-Antibodies, Neoplasm,
pubmed-meshheading:15068853-Antigens, CD,
pubmed-meshheading:15068853-Antigens, Differentiation,
pubmed-meshheading:15068853-Autoantigens,
pubmed-meshheading:15068853-Autoimmunity,
pubmed-meshheading:15068853-CTLA-4 Antigen,
pubmed-meshheading:15068853-Cancer Vaccines,
pubmed-meshheading:15068853-Cell Line, Tumor,
pubmed-meshheading:15068853-Flow Cytometry,
pubmed-meshheading:15068853-Humans,
pubmed-meshheading:15068853-Immunity, Cellular,
pubmed-meshheading:15068853-Immunization Schedule,
pubmed-meshheading:15068853-Immunosuppressive Agents,
pubmed-meshheading:15068853-Male,
pubmed-meshheading:15068853-Melanoma, Experimental,
pubmed-meshheading:15068853-Mice,
pubmed-meshheading:15068853-Mice, Inbred BALB C,
pubmed-meshheading:15068853-Mice, Inbred C57BL,
pubmed-meshheading:15068853-Neoplasm Transplantation,
pubmed-meshheading:15068853-Neoplasms,
pubmed-meshheading:15068853-Plasmids,
pubmed-meshheading:15068853-Prostate,
pubmed-meshheading:15068853-T-Lymphocytes,
pubmed-meshheading:15068853-Vaccines, DNA
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pubmed:year |
2004
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pubmed:articleTitle |
CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems.
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pubmed:affiliation |
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. gregorp@mskcc.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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