| pubmed-article:15059848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:15059848 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:15059848 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15059848 | pubmed:dateCreated | 2004-7-2 | lld:pubmed |
| pubmed-article:15059848 | pubmed:abstractText | CD8(+) T cells play a crucial role in the control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. Recent data suggest that HIV-1-specific CD8(+) T cell subsets may differ in their ability to exert these effector functions. Here, we directly compared the cytokine secretion patterns and cytotoxic capacity of HIV-1-specific CD8(+) T cells, using a flow-cytometric cytotoxicity assay based on caspase-3 activation in dying target cells. These experiments revealed considerable intraindividual and interindividual differences among epitope-specific T-cell effector functions: while the frequency of HIV-1-specific CD8(+) T cells secreting interferon-gamma but no tumor necrosis factor-alpha (TNF-alpha) following antigenic stimulation was only weakly correlated to their cytotoxic activity (R = 0.05, P =.57), a subset of CD8(+) T cells secreting both inter-feron-gamma and TNF-alpha was substantially more strongly associated with cytotoxicity (R = 0.67, P <.001). This subset of CD8(+) T cells also exhibited stronger intracellular perforin expression and more pronounced direct ex vivo HIV-1-specific cytoxicity than CD8(+) T cells secreting solely interferon-gamma following sorting of these subpopulations according to their cytokine profile. These results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentially mediated by a subset of CD8(+) T cells secreting both interferon-gamma and TNF-alpha. | lld:pubmed |
| pubmed-article:15059848 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15059848 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15059848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15059848 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15059848 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:AllenTodd MTM | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:WalkerBruce... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:LichterfeldMa... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:YuXu GXG | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:AddoMarylyn... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:StrickDaryldD | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:RosenbergEric... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:AltfeldMarcus... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:ZaundersJohnJ | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:AlterGalitG | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:CohenDanielD | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:JohnstonMary... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:PaeEuniceE | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:WaringMichael... | lld:pubmed |
| pubmed-article:15059848 | pubmed:author | pubmed-author:MuiStanley... | lld:pubmed |
| pubmed-article:15059848 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15059848 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15059848 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:15059848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15059848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15059848 | pubmed:pagination | 487-94 | lld:pubmed |
| pubmed-article:15059848 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15059848 | pubmed:meshHeading | pubmed-meshheading:15059848... | lld:pubmed |
| pubmed-article:15059848 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15059848 | pubmed:articleTitle | HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. | lld:pubmed |
| pubmed-article:15059848 | pubmed:affiliation | Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Rm 6613, Boston, MA 02129, USA. | lld:pubmed |
| pubmed-article:15059848 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15059848 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15059848 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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