|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0040300,
umls-concept:C0040690,
umls-concept:C0086597,
umls-concept:C0597357,
umls-concept:C1332714,
umls-concept:C1514485,
umls-concept:C1515655,
umls-concept:C1521840,
umls-concept:C1704675,
umls-concept:C1704711,
umls-concept:C1879547
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pubmed:issue |
4
|
|
pubmed:dateCreated |
2004-3-29
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|
pubmed:abstractText |
CD4(+) effector T cells generated in mesenteric lymph nodes (mLN) leave into the blood. Although they enter many tissues, mLN effector T cells are later found preferentially in the gut,the drainage area of mLN. We show in the rat that this is not an intrinsic property of mLN T cells. Instead, within the mLN milieu T cells are instructed by cytokines such as transforming growth factor beta 1 (TGF-beta 1) to up-regulate TGF-beta receptor II (TGF-beta RII) during activation. This enables effector T cells to continue proliferation upon subsequent contact with TGF-beta 1 in mLN and gut, and to accumulate in the lymph node draining area, the most likely site of pathogen invasion.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2980
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1050-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15048715-Animals,
pubmed-meshheading:15048715-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15048715-Cell Division,
pubmed-meshheading:15048715-Lymph Nodes,
pubmed-meshheading:15048715-Lymphocyte Activation,
pubmed-meshheading:15048715-Mesentery,
pubmed-meshheading:15048715-Rats,
pubmed-meshheading:15048715-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:15048715-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15048715-Transforming Growth Factor beta,
pubmed-meshheading:15048715-Transforming Growth Factor beta1,
pubmed-meshheading:15048715-Transforming Growth Factor beta2
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
CD4+ effector T cell distribution in vivo: TGF-beta 1/TGF-beta receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation.
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pubmed:affiliation |
Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. Bode.Ulrike@MH-Hannover.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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