Linked Life Data

15039761

Source:http://linkedlifedata.com/resource/pubmed/id/15039761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-4-20
pubmed:abstractText
Concurrent abuse of cocaine and heroin is a common problem. Methadone is effective for opioid dependence. The question arises as to whether combining agonist-like or antagonist-like medication for cocaine with methadone for opioid dependence might be efficacious. Two parallel studies were conducted. One examined sustained release d-amphetamine and the other risperidone for cocaine dependence, each in combination with methadone. In total, 240 subjects (120/study) were recruited, who were both cocaine and heroin dependent and not currently receiving medication. All provided consent. Both studies were carried out for 26 weeks, randomized, double-blind and placebo controlled. Study I compared sustained release d-amphetamine (escalating 15-30 or 30-60 mg) and placebo. Study II examined risperidone (2 or 4 mg) and placebo. All subjects underwent methadone induction and were stabilized at 1.1 mg/kg. Subjects attended clinic twice/week, provided urine samples, obtained medication take-home doses for intervening days, and completed self-report measures. Each had one behavioral therapy session/week. In Study I, reduction in cocaine use was significant for the 30/60 mg dose compared to the 15/30 mg and placebo. Opioid use was reduced in all groups with a trend toward greater reduction in the 30/60 mg d-amphetamine group. In Study II, methadone reduced illicit opioid use but cocaine use did not change in the risperidone or placebo groups. There were no adverse medication interactions in either study. The results provide support for the agonist-like (d-amphetamine) model in cocaine dependence treatment but not for antagonist-like (risperidone) treatment. They coincide with our previous reports of amphetamine or risperidone administered singly in cocaine-dependent individuals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
969-81
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed-meshheading:15039761-Adolescent, pubmed-meshheading:15039761-Adult, pubmed-meshheading:15039761-Blood Pressure, pubmed-meshheading:15039761-Cocaine, pubmed-meshheading:15039761-Cocaine-Related Disorders, pubmed-meshheading:15039761-Cognitive Therapy, pubmed-meshheading:15039761-Dextroamphetamine, pubmed-meshheading:15039761-Dopamine Antagonists, pubmed-meshheading:15039761-Dopamine Uptake Inhibitors, pubmed-meshheading:15039761-Double-Blind Method, pubmed-meshheading:15039761-Female, pubmed-meshheading:15039761-HIV Infections, pubmed-meshheading:15039761-Heroin Dependence, pubmed-meshheading:15039761-Humans, pubmed-meshheading:15039761-Male, pubmed-meshheading:15039761-Methadone, pubmed-meshheading:15039761-Middle Aged, pubmed-meshheading:15039761-Narcotics, pubmed-meshheading:15039761-Patient Dropouts, pubmed-meshheading:15039761-Psychiatric Status Rating Scales, pubmed-meshheading:15039761-Risperidone, pubmed-meshheading:15039761-Substance Abuse Detection
pubmed:year
2004
pubmed:articleTitle
Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, School of Medicine, Substance Abuse-Mediation Development Research Center, University of Texas-Health Science Center, Houston, TX 77030, USA. john.grabowski@uth.tmc.edu
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial