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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-19
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pubmed:abstractText |
During convergent extension in Drosophila, polarized cell movements cause the germband to narrow along the dorsal-ventral (D-V) axis and more than double in length along the anterior-posterior (A-P) axis. This tissue remodeling requires the correct patterning of gene expression along the A-P axis, perpendicular to the direction of cell movement. Here, we demonstrate that A-P patterning information results in the polarized localization of cortical proteins in intercalating cells. In particular, cell fate differences conferred by striped expression of the even-skipped and runt pair-rule genes are both necessary and sufficient to orient planar polarity. This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders. Moreover, bazooka mutants are defective for germband extension. These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Armadillo Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CD150 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/armadillo protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/bazooka protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/eve protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/run protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
343-55
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pubmed:dateRevised |
2008-10-15
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pubmed:meshHeading |
pubmed-meshheading:15030758-Animals,
pubmed-meshheading:15030758-Animals, Genetically Modified,
pubmed-meshheading:15030758-Antigens, CD,
pubmed-meshheading:15030758-Armadillo Domain Proteins,
pubmed-meshheading:15030758-Body Patterning,
pubmed-meshheading:15030758-Carrier Proteins,
pubmed-meshheading:15030758-Cell Adhesion Molecules,
pubmed-meshheading:15030758-Cell Movement,
pubmed-meshheading:15030758-Cell Polarity,
pubmed-meshheading:15030758-DNA-Binding Proteins,
pubmed-meshheading:15030758-Drosophila,
pubmed-meshheading:15030758-Drosophila Proteins,
pubmed-meshheading:15030758-Embryo, Nonmammalian,
pubmed-meshheading:15030758-Embryonic Induction,
pubmed-meshheading:15030758-Female,
pubmed-meshheading:15030758-Gene Expression Regulation,
pubmed-meshheading:15030758-Genes, Insect,
pubmed-meshheading:15030758-Glycoproteins,
pubmed-meshheading:15030758-Homeodomain Proteins,
pubmed-meshheading:15030758-Immunoglobulins,
pubmed-meshheading:15030758-Immunohistochemistry,
pubmed-meshheading:15030758-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15030758-Male,
pubmed-meshheading:15030758-Mutation,
pubmed-meshheading:15030758-Myosin Type II,
pubmed-meshheading:15030758-Nuclear Proteins,
pubmed-meshheading:15030758-Receptors, Cell Surface,
pubmed-meshheading:15030758-Trans-Activators,
pubmed-meshheading:15030758-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Patterned gene expression directs bipolar planar polarity in Drosophila.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA. jzallen@molbio.princeton.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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