| pubmed-article:15019206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0031955 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0036983 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C0768986 | lld:lifeskim |
| pubmed-article:15019206 | lifeskim:mentions | umls-concept:C1527211 | lld:lifeskim |
| pubmed-article:15019206 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15019206 | pubmed:dateCreated | 2004-3-15 | lld:pubmed |
| pubmed-article:15019206 | pubmed:abstractText | The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 X 10(10) CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach. | lld:pubmed |
| pubmed-article:15019206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15019206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15019206 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15019206 | pubmed:issn | 0196-9781 | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:CirioniOscarO | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:GiacomettiAnd... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:GhiselliRober... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:MocchegianiFe... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:OrlandoFioren... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:SabaVittorioV | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:ScaliseGiorgi... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:KamyszWojciec... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:ViticchiClaud... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:D'AmatoGiusep... | lld:pubmed |
| pubmed-article:15019206 | pubmed:author | pubmed-author:?LukasiakJerz... | lld:pubmed |
| pubmed-article:15019206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15019206 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15019206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15019206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15019206 | pubmed:pagination | 1747-52 | lld:pubmed |
| pubmed-article:15019206 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
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| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:meshHeading | pubmed-meshheading:15019206... | lld:pubmed |
| pubmed-article:15019206 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:15019206 | pubmed:articleTitle | Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock. | lld:pubmed |
| pubmed-article:15019206 | pubmed:affiliation | Institute of Infectious Diseases and Public Health, Clinica delle Malattie Infettive, Università Politecnica delle Marche, c/o Ospedale Regionale, Via Conca, 60020 Torrette AN, Ancona, Italy. anconacmi@interfree.it | lld:pubmed |
| pubmed-article:15019206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15019206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
