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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-3-15
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pubmed:abstractText |
The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 X 10(10) CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0196-9781
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pubmed:author |
pubmed-author:?LukasiakJerzyJ,
pubmed-author:CirioniOscarO,
pubmed-author:D'AmatoGiuseppinaG,
pubmed-author:Del PreteMaria SimonaMS,
pubmed-author:GhiselliRobertoR,
pubmed-author:GiacomettiAndreaA,
pubmed-author:KamyszWojciechW,
pubmed-author:MocchegianiFedericoF,
pubmed-author:OrlandoFiorenzaF,
pubmed-author:SabaVittorioV,
pubmed-author:ScaliseGiorgioG,
pubmed-author:ViticchiClaudioC
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1747-52
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15019206-Animals,
pubmed-meshheading:15019206-Antimicrobial Cationic Peptides,
pubmed-meshheading:15019206-Cecum,
pubmed-meshheading:15019206-Disease Models, Animal,
pubmed-meshheading:15019206-Drug Therapy, Combination,
pubmed-meshheading:15019206-Escherichia coli Infections,
pubmed-meshheading:15019206-Ligation,
pubmed-meshheading:15019206-Lipopolysaccharides,
pubmed-meshheading:15019206-Male,
pubmed-meshheading:15019206-Microbial Sensitivity Tests,
pubmed-meshheading:15019206-Peptides,
pubmed-meshheading:15019206-Peritonitis,
pubmed-meshheading:15019206-Piperacillin,
pubmed-meshheading:15019206-Proteins,
pubmed-meshheading:15019206-Punctures,
pubmed-meshheading:15019206-Rats,
pubmed-meshheading:15019206-Rats, Wistar,
pubmed-meshheading:15019206-Shock, Septic
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pubmed:year |
2003
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pubmed:articleTitle |
Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock.
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pubmed:affiliation |
Institute of Infectious Diseases and Public Health, Clinica delle Malattie Infettive, Università Politecnica delle Marche, c/o Ospedale Regionale, Via Conca, 60020 Torrette AN, Ancona, Italy. anconacmi@interfree.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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