|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
2004-2-27
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|
pubmed:abstractText |
Visceral hypersensitivity is a common feature of functional gastrointestinal disorders. One speculated mechanism is an activity-dependent increase in spinal cord neuronal excitability (central sensitization), which is dependent on activation of the N-methyl-D-aspartate (NMDA) receptor. Our aims were to determine whether the development and maintenance of human visceral hypersensitivity is NMDA receptor mediated.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0016-5085
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
126
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
683-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14988822-Adult,
pubmed-meshheading:14988822-Area Under Curve,
pubmed-meshheading:14988822-Attention,
pubmed-meshheading:14988822-Cross-Over Studies,
pubmed-meshheading:14988822-Double-Blind Method,
pubmed-meshheading:14988822-Electric Stimulation,
pubmed-meshheading:14988822-Esophagus,
pubmed-meshheading:14988822-Excitatory Amino Acid Antagonists,
pubmed-meshheading:14988822-Foot,
pubmed-meshheading:14988822-Humans,
pubmed-meshheading:14988822-Hydrochloric Acid,
pubmed-meshheading:14988822-Hyperalgesia,
pubmed-meshheading:14988822-Ketamine,
pubmed-meshheading:14988822-Pain Threshold,
pubmed-meshheading:14988822-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:14988822-Viscera
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.
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|
pubmed:affiliation |
GI Science Group, Hope Hospital, Salford, United Kingdom.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
