| pubmed-article:14982994 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0070876 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0872252 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14982994 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14982994 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:14982994 | pubmed:dateCreated | 2004-2-25 | lld:pubmed |
| pubmed-article:14982994 | pubmed:abstractText | Phospholamban (PLN) is a critical regulator of cardiac contractility through its binding to and regulation of the activity of the sarco(endo)plasmic reticulum Ca2+ ATPase. To uncover biochemical adaptations associated with extremes of cardiac muscle contractility, we used high-throughput gel-free tandem MS to monitor differences in the relative abundance of membrane proteins in standard microsomal fractions isolated from the hearts of PLN-null mice (PLN-KO) with high contractility and from transgenic mice overexpressing a superinhibitory PLN mutant in a PLN-null background (I40A-KO) with diminished contractility. Significant differential expression was detected for a subset of the 782 proteins identified, including known membrane-associated biomarkers, components of signaling pathways, and previously uninvestigated proteins. Proteins involved in fat and carbohydrate metabolism and proteins linked to G protein-signaling pathways activating protein kinase C were enriched in I40A-KO cardiac muscle, whereas proteins linked to enhanced contractile function were enriched in PLN-KO mutant hearts. These data demonstrate that Ca2+ dysregulation, leading to elevated or depressed cardiac contractility, induces compensatory biochemical responses. | lld:pubmed |
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| pubmed-article:14982994 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14982994 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14982994 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14982994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14982994 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14982994 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14982994 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:GramoliniAnth... | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:EmiliAndrewA | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:MacLennanDavi... | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:KraniasEvange... | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:KislingerThom... | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:PanYanY | lld:pubmed |
| pubmed-article:14982994 | pubmed:author | pubmed-author:ZvaritchElena... | lld:pubmed |
| pubmed-article:14982994 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14982994 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:14982994 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:14982994 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14982994 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14982994 | pubmed:pagination | 2241-6 | lld:pubmed |
| pubmed-article:14982994 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14982994 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14982994 | pubmed:articleTitle | Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. | lld:pubmed |
| pubmed-article:14982994 | pubmed:affiliation | Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6. | lld:pubmed |
| pubmed-article:14982994 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14982994 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14982994 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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