Source:http://linkedlifedata.com/resource/pubmed/id/14980514
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-2-24
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pubmed:abstractText |
The heterogeneous nuclear ribonucleoproteins (hnRNPs) F and H/H', containing the quasi-RNA recognition motif (qRRM) domains, are implicated in several steps of pre-mRNA processing and in cellular differentiation. We have compared a set of tissues and found striking differences in their levels of expression as well as in the nuclear versus the cytoplasmic distribution. Generally, hnRNP F is broadly expressed in many tissues with extremely strong expression in the prostate gland while hnRNP H/H' shows a more restricted degree of expression with low expression in some tissues, for example, liver, exocrine acini of the pancreas, thyroid gland and heart. At the cellular level, hnRNP F is, with few exceptions, predominantly expressed in the cytoplasm while hnRNP H/H' is more abundant in the nuclei. A quite pronounced heterogeneous expression pattern is seen in the proximal tubules of the kidney where hnRNP F is present at moderate cytoplasmic levels while hnRNP H/H' is undetectable, whereas both proteins are more evenly expressed in distal tubules and collecting ducts. Generally, tumor tissues reveal a broad expression of hnRNP F in the nuclei as well as in the cytoplasm while hnRNP H/H' is expressed at higher levels in the nuclei than in the cytoplasm. Up-regulation of hnRNP H/H' is found in a few tissues that normally express low cytoplasmic levels of hnRNP H/H', for example, adenocarcinoma of the pancreas, hepatocellular carcinoma and gastric carcinoma. hnRNP F is down-regulated in hepatocellular carcinoma and up-regulated in gastric carcinoma. The present study indicates the important potential role of this subset of hnRNPs on the gene expression in many tissues.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-4827
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-209
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14980514-Adenocarcinoma,
pubmed-meshheading:14980514-Carcinoma, Hepatocellular,
pubmed-meshheading:14980514-Heterogeneous-Nuclear Ribonucleoprotein Group F-H,
pubmed-meshheading:14980514-Humans,
pubmed-meshheading:14980514-Immunohistochemistry,
pubmed-meshheading:14980514-Liver Neoplasms,
pubmed-meshheading:14980514-Neoplasms,
pubmed-meshheading:14980514-Pancreatic Neoplasms,
pubmed-meshheading:14980514-Tissue Distribution,
pubmed-meshheading:14980514-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues.
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pubmed:affiliation |
Department of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus C, Denmark. bh@biokemi.au.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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