Linked Life Data

14907956

Source:http://linkedlifedata.com/resource/pubmed/id/14907956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1952-12-1
pubmed:abstractText
The early phase of growth of the Lansing strain of poliomyelitis virus in the mouse brain and cord was suppressed, or delayed, by the intraperitoneal administration of sodium monofluoroacetate in doses of 6 mg./kg. but not of 3 mg./kg. 1 hour before the intracerebral inoculation of virus. There was also a delay in the time at which the first signs of illness appeared in the treated mice. Similar effects, but to a lesser degree, were observed after the administration of DL-methionine sulfoximine in doses of 150 mg./kg. and 75 mg./kg. Sodium fluoroacetate in very high concentration had no direct effect in vitro on the infectivity of poliomyelitis virus. It was found that in each instance in which the growth of virus was delayed, the time at which the first obvious signs of illness appeared was also delayed in a proportionate manner. The significance of these findings is discussed, as well as the use of the growth curve of poliomyelitis virus in mice in studying the relation of cellular metabolism to viral synthesis and the search for effective chemical agents.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
OLDMEDLINE
pubmed:month
Jan
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-18
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1952
pubmed:articleTitle
The growth curve of the Lansing strain of poliomyelitis virus in mice: the effect of sodium monofluoroacetate and methionine sulfoximine on the early phase of growth of the virus.
pubmed:publicationType
Journal Article