Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1993-2-18
pubmed:abstractText
Sequentially obtained serum samples from 30 patients with connective tissue disease positive for antibody to ribonucleoprotein (RNP) were examined to determine the specificities of IgG and IgM antibodies to snRNP during the disease course using immunoblotting of nuclear extracts. The antibody patterns were correlated with disease activity. The patterns of antibody to snRNP of individual patients were mainly stable during the study but changes in levels of antibody to snRNP were seen corresponding to changes in clinical activity. These results indicate that increased reactivity of serum IgM antibodies against the B/B' proteins seems to precede a clinically evident exacerbation of disease whereas IgG antibody reactivity to the 70 K protein peaks at the time of a disease flare.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-1696183, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-1701488, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-1765975, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-1825188, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-2140681, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-2383062, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-2521585, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-2646863, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-3062767, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-316537, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-3261966, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-3488746, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-3858987, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-3884199, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-4621694, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-5932578, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-6185498, http://linkedlifedata.com/resource/pubmed/commentcorrection/1485812-6232278
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1307-12
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
IgG and IgM anti-snRNP reactivity in sequentially obtained serum samples from patients with connective tissue diseases.
pubmed:affiliation
Department of Medical Cell Genetics, Karolinska Institutet, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't