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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
5-6
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pubmed:dateCreated |
1993-2-12
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pubmed:abstractText |
In this work the authors studied the effects of interleukin-1 alpha on metabolic activities of human osteoblast-like cells in vitro. The bone nature of the cells was established by assaying for specific bone protein, the osteonectin, and the parathormone receptor, an osteoblast marker. Administration of interleukin-1 alpha to cultured osteoblasts produce an increase in cellular proliferation as suggested by 3H-thymidine incorporation and cell growth studies. Interleukin-1 alpha also affected collagen synthesis confirming its potential role on bone-formation and resorption processes.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0145-5680
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|
pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
679-86
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1483116-Adenylate Cyclase,
pubmed-meshheading:1483116-Adult,
pubmed-meshheading:1483116-Cell Division,
pubmed-meshheading:1483116-Cells, Cultured,
pubmed-meshheading:1483116-Collagen,
pubmed-meshheading:1483116-DNA,
pubmed-meshheading:1483116-Dose-Response Relationship, Drug,
pubmed-meshheading:1483116-Humans,
pubmed-meshheading:1483116-Interleukin-1,
pubmed-meshheading:1483116-Leucine,
pubmed-meshheading:1483116-Osteoblasts,
pubmed-meshheading:1483116-Parathyroid Hormone,
pubmed-meshheading:1483116-Propranolol,
pubmed-meshheading:1483116-Protein Biosynthesis,
pubmed-meshheading:1483116-Recombinant Proteins,
pubmed-meshheading:1483116-Thymidine,
pubmed-meshheading:1483116-Tritium
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pubmed:articleTitle |
Interleukin-1 alpha: regulation of cellular proliferation and collagen synthesis in cultured human osteoblast-like cells.
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pubmed:affiliation |
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi Perugia, Italie.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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