Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1993-2-12
pubmed:abstractText
Some biosynthetic activities of normal and otosclerotic temporal bone cultures have been studied. Bone cells were cultured for 24 hrs. in medium containing 3H-glucosamine, 35SO4 or 3H-proline. Labelled glycosaminoglycans (GAG) and proteins were precipitated from cells and media. In otosclerotic bone cells there was an evident reduction in the synthesis and secretion of radiolabelled macromolecules. The inhibitory effect was always greater in the extracellular than in the intracellular compartment. Some glycosidases were also studied. Otosclerosis decreased the activity of all enzymes examined, indicating that the lower GAG synthesis and secretion in otosclerotic bone cells were not due to an increased degradation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-5680
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
635-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Synthesis and secretion of glycosaminoglycans and proteins in human normal and otosclerotic bone cells.
pubmed:affiliation
Dipartimento di Medicina Sperimentale, Università di Perugia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't