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rdf:type |
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lifeskim:mentions |
umls-concept:C0007367,
umls-concept:C0010453,
umls-concept:C0025462,
umls-concept:C0027746,
umls-concept:C0038838,
umls-concept:C0282151,
umls-concept:C0920591,
umls-concept:C1151619,
umls-concept:C1280500,
umls-concept:C1704945,
umls-concept:C1721379,
umls-concept:C2826280
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pubmed:issue |
1-2
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|
pubmed:dateCreated |
2004-1-26
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|
pubmed:abstractText |
Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencephalic neuroglia cultures. MnTMPyP exhibited a significantly protective effect against LPS (5 ng/ml)-induced neurotoxicity as determined by [3H]dopamine uptake and immunocytochemical analysis. MnTMPyP significantly attenuated LPS-induced production of superoxide free radical and prostaglandin E(2) (PGE(2)) in microglia. These results indicate that MnTMPyP may potentially be used for the treatment of inflammation-related degenerative neurological disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14741430-Analysis of Variance,
pubmed-meshheading:14741430-Animals,
pubmed-meshheading:14741430-Animals, Newborn,
pubmed-meshheading:14741430-Catalase,
pubmed-meshheading:14741430-Cells, Cultured,
pubmed-meshheading:14741430-Dinoprostone,
pubmed-meshheading:14741430-Dopamine,
pubmed-meshheading:14741430-Dose-Response Relationship, Drug,
pubmed-meshheading:14741430-Drug Interactions,
pubmed-meshheading:14741430-Free Radical Scavengers,
pubmed-meshheading:14741430-Immunohistochemistry,
pubmed-meshheading:14741430-Lipopolysaccharides,
pubmed-meshheading:14741430-Mesencephalon,
pubmed-meshheading:14741430-Metalloporphyrins,
pubmed-meshheading:14741430-Molecular Mimicry,
pubmed-meshheading:14741430-Nerve Degeneration,
pubmed-meshheading:14741430-Neuroglia,
pubmed-meshheading:14741430-Neurons,
pubmed-meshheading:14741430-Rats,
pubmed-meshheading:14741430-Rats, Inbred F344,
pubmed-meshheading:14741430-Superoxide Dismutase,
pubmed-meshheading:14741430-Superoxides,
pubmed-meshheading:14741430-Tritium
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pubmed:year |
2004
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pubmed:articleTitle |
Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures.
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pubmed:affiliation |
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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