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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2004-1-26
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pubmed:abstractText |
Retinoic acid receptor-related orphan receptor-alpha (RORalpha) is a nuclear orphan receptor. Adenovirus-mediated overexpression of RORalpha1 and RORalpha4 suppressed tumor necrosis factor-alpha (TNF-alpha)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells. Overexpression of RORalpha1 and RORalpha4 also suppressed TNF-alpha-stimulated translocation of p50 and p65 to the nucleus. In contrast, dominant-negative deletion mutants of RORalpha1 and RORalpha4 failed to suppress the induction of VCAM-1 and ICAM-1 and translocations of p50 and p65. These results suggest that RORalpha1 and RORalpha4 regulate the inflammatory responses via inhibition of the nuclear factor-kappaB signaling pathway in endothelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/ROR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RORA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Tyrosine Kinase-like...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
557
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-74
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14741380-Animals,
pubmed-meshheading:14741380-Cell Line,
pubmed-meshheading:14741380-Cells, Cultured,
pubmed-meshheading:14741380-DNA Primers,
pubmed-meshheading:14741380-Endothelium, Vascular,
pubmed-meshheading:14741380-Gene Expression Regulation,
pubmed-meshheading:14741380-Genes, Reporter,
pubmed-meshheading:14741380-Humans,
pubmed-meshheading:14741380-Intercellular Adhesion Molecule-1,
pubmed-meshheading:14741380-Luciferases,
pubmed-meshheading:14741380-Nuclear Receptor Subfamily 1, Group F, Member 1,
pubmed-meshheading:14741380-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:14741380-Receptor Tyrosine Kinase-like Orphan Receptors,
pubmed-meshheading:14741380-Receptors, Cell Surface,
pubmed-meshheading:14741380-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:14741380-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14741380-Trans-Activators,
pubmed-meshheading:14741380-Transfection,
pubmed-meshheading:14741380-Tumor Necrosis Factor-alpha,
pubmed-meshheading:14741380-Umbilical Veins,
pubmed-meshheading:14741380-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2004
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pubmed:articleTitle |
RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.
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pubmed:affiliation |
Cardiovascular Research, Drug Discovery Institute, Nihon Schering KK, 1900-1, Togo Mobara, Chiba 297-0017, Japan. migitabb@yahoo.co.jp
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pubmed:publicationType |
Journal Article
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