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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-1-26
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pubmed:abstractText |
TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 microM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14741264-Animals,
pubmed-meshheading:14741264-Ascomycota,
pubmed-meshheading:14741264-Cysteine Endopeptidases,
pubmed-meshheading:14741264-Molecular Structure,
pubmed-meshheading:14741264-Multienzyme Complexes,
pubmed-meshheading:14741264-Neurites,
pubmed-meshheading:14741264-PC12 Cells,
pubmed-meshheading:14741264-Peptides, Cyclic,
pubmed-meshheading:14741264-Protease Inhibitors,
pubmed-meshheading:14741264-Proteasome Endopeptidase Complex,
pubmed-meshheading:14741264-Rats
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pubmed:year |
2004
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pubmed:articleTitle |
TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells.
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pubmed:affiliation |
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. inoue@ykbsc.chem.tohoku.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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