Source:http://linkedlifedata.com/resource/pubmed/id/14734737
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-1-21
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| pubmed:abstractText |
The success of the cutaneous immune system reflects its ability to rapidly and efficiently recruit leukocytes to areas of trauma and infection. Skin-homing memory T cells expressing cutaneous lymphocyte-associated Ag tether on the walls of postcapillary venules in inflamed skin via interaction with endothelial E-selectin and roll in response to the shear stress imparted by flowing blood. Rolling cells sample the vascular surface for chemoattractant compounds (e.g., thymus- and activation-regulated chemokine/CCL17 interacting with CCR4 on the leukocyte surface) and, if successfully stimulated, progress to firm arrest and transmigration mediated by LFA-1 and vascular ICAM-1. Although it is established that this sequence of events draws T cells into inflamed skin, the mechanisms directing trafficking of T cells to noninflamed skin are less well characterized. We hypothesized that basal expression and colocalization of E-selectin, chemokine (e.g., CCL17), and ICAM-1 in dermal vessels could serve to recruit T cells to noninflamed human skin. Immunohistochemical staining for E-selectin and CD31 demonstrated E-selectin expression in a restricted subset of dermal vessels in noninflamed human skin from three different sites. Confocal multicolor immunofluorescence imaging revealed a nonuniform distribution of E-selectin in dermal vessels as well as colocalization of E-selectin with CCL17 and ICAM-1. Coexpression of these molecules on blood vessels in noninflamed skin provides the basis for a model of cutaneous immunosurveillance system active in the absence of pathologic inflammation.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/CCL17 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL17,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
172
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1575-81
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14734737-Antigens, CD31,
pubmed-meshheading:14734737-Cell Movement,
pubmed-meshheading:14734737-Chemokine CCL17,
pubmed-meshheading:14734737-Chemokines, CC,
pubmed-meshheading:14734737-E-Selectin,
pubmed-meshheading:14734737-Endothelium, Vascular,
pubmed-meshheading:14734737-Humans,
pubmed-meshheading:14734737-Immunohistochemistry,
pubmed-meshheading:14734737-Immunologic Memory,
pubmed-meshheading:14734737-Intercellular Adhesion Molecule-1,
pubmed-meshheading:14734737-Lymphocyte Activation,
pubmed-meshheading:14734737-Microcirculation,
pubmed-meshheading:14734737-Microscopy, Fluorescence,
pubmed-meshheading:14734737-Models, Immunological,
pubmed-meshheading:14734737-Monitoring, Immunologic,
pubmed-meshheading:14734737-Skin,
pubmed-meshheading:14734737-T-Lymphocyte Subsets,
pubmed-meshheading:14734737-Thymus Gland
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| pubmed:year |
2004
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| pubmed:articleTitle |
E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.
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| pubmed:affiliation |
Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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