| pubmed-article:14732344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14732344 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:14732344 | lifeskim:mentions | umls-concept:C2753904 | lld:lifeskim |
| pubmed-article:14732344 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14732344 | pubmed:dateCreated | 2004-1-20 | lld:pubmed |
| pubmed-article:14732344 | pubmed:abstractText | We have previously shown an increase in intestinal permeability and a corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of patients with Crohn's disease (CD). Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin, and the claudins are key proteins in the TJ. Hypothesis: TNFalpha disrupts the TJ. | lld:pubmed |
| pubmed-article:14732344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14732344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14732344 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14732344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14732344 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14732344 | pubmed:issn | 0022-4804 | lld:pubmed |
| pubmed-article:14732344 | pubmed:author | pubmed-author:PoritzLisa... | lld:pubmed |
| pubmed-article:14732344 | pubmed:author | pubmed-author:KoltunWalter... | lld:pubmed |
| pubmed-article:14732344 | pubmed:author | pubmed-author:TilbergAnna... | lld:pubmed |
| pubmed-article:14732344 | pubmed:author | pubmed-author:GarverKristia... | lld:pubmed |
| pubmed-article:14732344 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14732344 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:14732344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14732344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14732344 | pubmed:pagination | 14-8 | lld:pubmed |
| pubmed-article:14732344 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14732344 | pubmed:meshHeading | pubmed-meshheading:14732344... | lld:pubmed |
| pubmed-article:14732344 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14732344 | pubmed:articleTitle | Tumor necrosis factor alpha disrupts tight junction assembly. | lld:pubmed |
| pubmed-article:14732344 | pubmed:affiliation | Department of Surgery, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. lporitz@psu.edu | lld:pubmed |
| pubmed-article:14732344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14732344 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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