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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-20
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pubmed:abstractText |
We have previously shown an increase in intestinal permeability and a corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of patients with Crohn's disease (CD). Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin, and the claudins are key proteins in the TJ. Hypothesis: TNFalpha disrupts the TJ.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14732344-Animals,
pubmed-meshheading:14732344-Cell Count,
pubmed-meshheading:14732344-Cell Line,
pubmed-meshheading:14732344-Dogs,
pubmed-meshheading:14732344-Fluorescent Antibody Technique,
pubmed-meshheading:14732344-Humans,
pubmed-meshheading:14732344-Immunoblotting,
pubmed-meshheading:14732344-Kidney,
pubmed-meshheading:14732344-Membrane Proteins,
pubmed-meshheading:14732344-Phosphoproteins,
pubmed-meshheading:14732344-Recombinant Proteins,
pubmed-meshheading:14732344-Staining and Labeling,
pubmed-meshheading:14732344-Tight Junctions,
pubmed-meshheading:14732344-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Tumor necrosis factor alpha disrupts tight junction assembly.
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pubmed:affiliation |
Department of Surgery, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. lporitz@psu.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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